Description

Dbco-Ss-Aldehyde (CAS NO 2749492-45-1) is a specialized heterobifunctional crosslinker designed for advanced bioconjugation and materials science applications. Its core value lies in combining the rapid, catalyst-free reactivity of the dibenzocyclooctyne (DBCO) group with the versatile aldehyde functionality, enabling sequential and orthogonal labeling strategies. This compound is essential for researchers and manufacturers in pharmaceutical development, proteomics, and polymer chemistry who require precise and efficient coupling of biomolecules or synthetic polymers.

Application

• Antibody-Drug Conjugate (ADC) Development: For site-specific conjugation of cytotoxic payloads to antibodies via aldehyde engineering or hydrazone/oxime chemistry.
• Protein and Peptide Labeling: Enables dual-functional modification of proteins, useful for creating fluorescent probes, affinity tags, or PEGylated constructs.
• Surface Functionalization: Immobilization of biomolecules onto aldehyde-reactive surfaces (e.g., amine-coated chips, beads) followed by DBCO-mediated click chemistry.
• Polymer Synthesis and Modification: Serves as a key monomer or end-group modifier for creating functionalized hydrogels, dendrimers, and block copolymers.
• Diagnostic Assay Development: Used in the fabrication of biosensors and immunoassay components requiring stable, oriented biomolecule attachment.
• Glycan and Carbohydrate Chemistry: Conjugation tool for labeling or immobilizing glycans via their reducing ends or engineered aldehyde groups.
• Materials Science Research: Building block for creating advanced materials with tailored bio-interfaces and responsive properties.

Basic Information

Product Name	Dbco-Ss-Aldehyde
CAS No.	2749492-45-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	DBCO-SS-CHO; Dibenzocyclooctyne-disulfide-aldehyde; (1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl (2-((2-(2-(2-(2-(4-formylbenzamido)ethoxy)ethoxy)ethoxy)ethyl)disulfanyl)ethyl)carbamate; Aldehyde-DBCO heterobifunctional crosslinker; DBCO-PEG4-SS-CHO; DBCO-SS-PEG4-CHO; SS-DBCO-CHO; DBCO-S-S-Aldehyde linker
EINECS	Contact for details

Quality Control

Our Dbco-Ss-Aldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and NMR for structural confirmation, to ensure consistency and reliability for critical research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, moisture-free environment. Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and hydrolysis. For long-term stability, recommend storing desiccated.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.