Description

Doxapram n-Oxide is a key pharmaceutical intermediate and metabolite of the respiratory stimulant doxapram. This compound is of significant interest for research and development in the fields of analytical chemistry, pharmacokinetics, and drug metabolism studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers of active pharmaceutical ingredients (APIs) for method development, impurity profiling, and reference standard applications.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the qualitative and quantitative analysis of doxapram and its related substances in compliance with pharmacopeial guidelines (e.g., USP, EP).
• Metabolite Studies: Serves as a critical standard in pharmacokinetic research to study the absorption, distribution, metabolism, and excretion (ADME) profile of doxapram.
• Impurity Profiling: Employed for the identification, characterization, and control of process-related impurities and degradation products in doxapram API manufacturing.
• Analytical Method Development: Essential for developing and validating stability-indicating assay methods, such as HPLC and LC-MS, for doxapram-based formulations.
• Biomedical Research: Used in preclinical and clinical studies to understand the pharmacological activity and safety profile of doxapram metabolites.

Basic Information

Product Name	Doxapram n-Oxide
CAS No.	2724726-82-1
Molecular Formula	C24H31N3O3
Molecular Weight	409.53 g/mol
Synonyms	Doxapram N-Oxide; 1-Ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone N-Oxide; Doxapram Impurity; Doxapram Related Compound; Doxapram Metabolite; 2-Pyrrolidinone, 1-ethyl-4-[2-(4-morpholinyl)ethyl]-3,3-diphenyl-, 1-oxide
EINECS	Contact for details

Quality Control

Our Doxapram n-Oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR, MS), purity determination by HPLC, and control of related substances. A Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment to ensure traceability and compliance with your research or quality control requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.