Description

4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Oxazole-2-Carboxylic Acid Ethyl Ester is a high-value, multifunctional heterocyclic building block that integrates a protected boronic ester with an oxazole carboxylic ester. This compound matters as a critical intermediate for modern synthetic chemistry, enabling efficient cross-coupling reactions and the construction of complex molecular architectures. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers for applications in drug discovery, agrochemical synthesis, and advanced material science.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those targeting kinase inhibition and other biological pathways.
• Suzuki-Miyaura Cross-Coupling: The pinacol boronic ester moiety serves as a versatile handle for palladium-catalyzed cross-coupling reactions with aryl/heteroaryl halides, enabling efficient C-C bond formation.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the oxazole core for bioactivity.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and organic semiconductors, where the conjugated oxazole system is valuable.
• Chemical Biology & Probe Development: Useful for creating molecular probes and bioconjugates due to its reactive ester and boryl groups, facilitating labeling and target engagement studies.
• Library Synthesis for High-Throughput Screening: An essential building block for generating diverse compound libraries in medicinal chemistry to explore new chemical space.

Basic Information

Product Name	4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Oxazole-2-Carboxylic Acid Ethyl Ester
CAS No.	2716848-85-8
Molecular Formula	C14H20BNO5
Molecular Weight	293.13 g/mol
Synonyms	Ethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-oxazole-2-carboxylate; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-oxazolecarboxylic Acid Ethyl Ester; 2-Oxazolecarboxylic acid, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, ethyl ester; 4-(Pinacolatoboryl)oxazole-2-carboxylic acid ethyl ester; 4-BPin-oxazole-2-COOEt; CAS 2716848-85-8
EINECS	Contact for details

Quality Control

Our 4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Oxazole-2-Carboxylic Acid Ethyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for sensitive synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.