Description

Pyridine, 2-[(1S)-1-Methoxyethyl]-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-value, chiral organoboron building block essential for modern synthetic chemistry. This compound matters because it combines a pyridine scaffold with a pinacol boronate ester and a chiral methoxyethyl side chain, enabling precise, stereoselective cross-coupling reactions. It is primarily needed by pharmaceutical and agrochemical R&D teams for constructing complex molecules, particularly in the synthesis of active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of complex drug candidates, especially for targets requiring stereochemical control.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester reagent for forming carbon-carbon bonds with aryl/heteroaryl halides under mild conditions.
• Agrochemical Synthesis: Used in the research and development of advanced, chiral pesticides and herbicides.
• Ligand and Catalyst Development: The pyridine nitrogen and chiral center make it a candidate for developing novel asymmetric catalysts and metal-chelating ligands.
• Material Science Research: Employed in creating functionalized organic molecules for organic electronics and advanced polymers.
• Chemical Biology Probes: Useful for synthesizing tagged or modified molecules for studying biological pathways and target engagement.

Basic Information

Product Name	Pyridine, 2-[(1S)-1-Methoxyethyl]-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	2641451-45-6
Molecular Formula	C14H22BNO3
Molecular Weight	263.14 g/mol
Synonyms	(S)-2-(1-Methoxyethyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 2-[(1S)-1-Methoxyethyl]-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 3-Pyridineboronic acid, 2-[(1S)-1-methoxyethyl]-, pinacol ester; (S)-3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(1-methoxyethyl)pyridine; Chiral Pyridine Boronic Ester; BoroPin Chiral Pyridine Derivative
EINECS	Contact for details

Quality Control

Our Pyridine, 2-[(1S)-1-Methoxyethyl]-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC, NMR, and LC-MS, to ensure high chemical and enantiomeric purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with full characterization data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a recommended temperature of 2-8°C for long-term stability. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
NMR Purity	Conforms to structure

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.