Description

1,3,2-Dioxaborolane, 2-(8-Fluoro-1-Naphthalenyl)-4,4,5,5-Tetramethyl- is a high-purity, advanced boronic ester derivative, serving as a critical synthetic intermediate in modern organic and medicinal chemistry. Its core value lies in enabling precise Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl scaffolds. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries who require reliable, high-quality building blocks for drug discovery and advanced material development.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing fluorinated naphthalene motifs.
• Suzuki-Miyaura Cross-Coupling: A versatile organoboron reagent for palladium-catalyzed carbon-carbon bond formation to create complex biaryl structures.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides with enhanced properties.
• Material Science Research: Precursor for the development of organic electronic materials, such as OLEDs and organic semiconductors.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands and organometallic catalysts.
• Chemical Biology Probes: Utilized in the creation of fluorophore-labeled or bioactive molecules for target identification and binding studies.

Basic Information

Product Name	1,3,2-Dioxaborolane, 2-(8-Fluoro-1-Naphthalenyl)-4,4,5,5-Tetramethyl-
CAS No.	2621932-49-6
Molecular Formula	C₁₈H₂₀BFO₂
Molecular Weight	298.16 g/mol
Synonyms	8-Fluoro-1-naphthaleneboronic acid pinacol ester; (8-Fluoronaphthalen-1-yl)boronic acid pinacol ester; 2-(8-Fluoro-1-naphthyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 8-Fluoro-1-naphthylboronic acid pinacol ester; 1-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-8-fluoronaphthalene; 8-Fluoronaphthalene-1-boronic acid pinacol ester; Naphthalene-1-boronic acid, 8-fluoro-, 1,3,2-dioxaborolane ester
EINECS	Contact for details

Quality Control

Our 1,3,2-Dioxaborolane, 2-(8-Fluoro-1-Naphthalenyl)-4,4,5,5-Tetramethyl- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with full analytical data are provided to guarantee consistency and traceability for your research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.