Description

2-(8-Ethyl-7-Fluoro-3-(Methoxymethoxy)Naphthalen-1-Yl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane CAS NO 2621932-48-5 is a high-purity, advanced pharmaceutical intermediate belonging to the class of naphthalene-based boronic acid pinacol esters. This compound is a critical building block in modern organic synthesis, particularly valued for its role in facilitating key carbon-carbon bond formation reactions. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a pivotal boronate ester reagent for constructing complex biaryl structures in drug discovery and development.
• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) targeting various therapeutic areas.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science: Employed in the synthesis of organic electronic materials, such as those used in OLEDs and semiconductors.
• Chemical Biology: Acts as a probe or building block in the synthesis of molecules for biological target identification and validation.
• Process Chemistry & Scale-up: Suitable for optimization and scaling from laboratory research to pilot and commercial manufacturing processes.

Basic Information

Product Name	2-(8-Ethyl-7-Fluoro-3-(Methoxymethoxy)Naphthalen-1-Yl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	2621932-48-5
Molecular Formula	C22H28BFO4
Molecular Weight	386.27 g/mol
Synonyms	8-Ethyl-7-fluoro-3-(methoxymethoxy)-1-naphthaleneboronic acid pinacol ester; 1-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-8-ethyl-7-fluoro-3-(methoxymethoxy)naphthalene; 2-(8-Ethyl-7-fluoro-3-(methoxymethoxy)naphthalen-1-yl)-1,3,2-dioxaborolane, 4,4,5,5-tetramethyl-; Boronic acid, B-[8-ethyl-7-fluoro-3-(methoxymethoxy)-1-naphthalenyl]-, 1,1-dimethylethyl ester; (8-Ethyl-7-fluoro-3-(methoxymethoxy)naphthalen-1-yl)boronic acid pinacol ester; Naphthalene-1-boronic acid derivative; Pinacol boronate ester intermediate
EINECS	Contact for details

Quality Control

Our 2-(8-Ethyl-7-Fluoro-3-(Methoxymethoxy)Naphthalen-1-Yl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided and available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Keep away from heat, sparks, and open flame. Due to its sensitivity, the container should be kept sealed and allowed to reach ambient temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.