Description

6-Fluoro-7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzofuran is a high-purity, advanced pharmaceutical intermediate and a key building block in modern synthetic chemistry. This compound matters for its critical role as a versatile boronic ester pinacol ester, enabling efficient cross-coupling reactions essential for constructing complex molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the synthesis of novel active ingredients and functional materials.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A pivotal reagent for forming carbon-carbon bonds in the synthesis of complex biaryl and heterobiaryl structures.
• Pharmaceutical Intermediate: Serves as a key building block in the research and development of new active pharmaceutical ingredients (APIs), particularly in oncology and CNS drug candidates.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, due to the benzofuran core.
• Chemical Biology & Probe Development: Utilized for synthesizing molecular probes and labeled compounds for diagnostic and research applications.
• Scale-up Process Chemistry: Suitable for process optimization and pilot-scale synthesis in cGMP and non-GMP environments.

Basic Information

Item	Details
Product Name	6-Fluoro-7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzofuran
CAS No.	2614262-12-1
Molecular Formula	C₁₄H₁₆BFO₃
Molecular Weight	262.09 g/mol
Synonyms	6-Fluoro-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-benzofuran; 6-Fluoro-7-benzofuranboronic acid pinacol ester; 6-Fluoro-7-(pinacolboranyl)benzofuran; 7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-6-fluorobenzofuran; 6-Fluoro-7-(pinacolatoboryl)benzofuran; 6-Fluoro-7-boronic acid pinacol ester benzofuran; 6-Fluoro-7-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran
EINECS	Contact for details

Quality Control

Our 6-Fluoro-7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzofuran is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for demanding synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.