Description

1-Pyrrolidinepropanoic Acid, 2-[[[7-(8-Chloro-1-Naphthalenyl)-4-[(3S)-3-(Cyanomethyl)-4-(2-Fluoro-1-Oxo-2-Propen-1-Yl)-1-Piperazinyl]-5,6,7,8- is a complex, high-purity synthetic intermediate designed for advanced pharmaceutical research and development. This compound is critical for medicinal chemists exploring novel therapeutic agents, particularly in targeted drug discovery programs. Its sophisticated molecular architecture makes it a valuable building block for synthesizing potential candidates in oncology and other specialized therapeutic areas, where precise chemical functionality is paramount.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel active pharmaceutical ingredients (APIs) for investigational drugs.
• Medicinal Chemistry Research: Used as a sophisticated scaffold or building block in structure-activity relationship (SAR) studies and lead optimization.
• Oncology Drug Discovery: Employed in the development of targeted cancer therapies due to its specific functional groups and chiral center.
• Chemical Biology Probes: Utilized in the creation of specialized molecular probes for studying biological pathways and target engagement.
• Process Chemistry Development: Acts as a critical intermediate during the scale-up and route scouting phases for new drug candidates.
• Custom Synthesis: Provided for contract research organizations (CROs) and pharmaceutical companies requiring bespoke, high-complexity intermediates.

Basic Information

Product Name	1-Pyrrolidinepropanoic Acid, 2-[[[7-(8-Chloro-1-Naphthalenyl)-4-[(3S)-3-(Cyanomethyl)-4-(2-Fluoro-1-Oxo-2-Propen-1-Yl)-1-Piperazinyl]-5,6,7,8-
CAS No.	2561529-96-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	2561529-96-0; (3S)-3-(Cyanomethyl)-1-[7-(8-chloronaphthalen-1-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl]-4-(2-fluoroacryloyl)piperazine-2-carboxylic acid; 2-[[[7-(8-Chloro-1-naphthalenyl)-5,6,7,8-tetrahydro-4-[(3S)-3-(cyanomethyl)-4-(2-fluoro-1-oxo-2-propen-1-yl)-1-piperazinyl]-5,6,7,8-; Advanced Pharmaceutical Intermediate 2561529-96-0; KRAS G12C Inhibitor Intermediate; Sotorasib-related Intermediate; MRTX-related Compound
EINECS	Contact for details

Quality Control

This high-value intermediate is manufactured under strict quality management systems to ensure batch-to-batch consistency and integrity. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity, purity, and the absence of critical impurities. Certificates of Analysis (COA) detailing all specification results are provided with each shipment. We support development needs with custom purity grades and analytical method support upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep at -20°C or below under an inert atmosphere. The compound is moisture-sensitive and should be handled in a dry environment. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Purity (HPLC, Anhydrous Basis)	≥ 98.0%
Single Unknown Impurity	≤ 1.0%
Total Impurities	≤ 3.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.