Description

1,3,2-Dioxaborolane, 2-[7-Fluoro-8-[2-[Tris(1-Methylethyl)Silyl]Ethynyl]-1-Naphthalenyl]-4,4,5,5-Tetramethyl- is a sophisticated, high-purity organoboron building block designed for advanced synthetic chemistry. This compound is critical for enabling cross-coupling reactions, particularly in the construction of complex molecular architectures. It is an essential intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science sectors who require reliable, high-quality reagents for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds containing complex naphthalene and fluoroaryl motifs.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a critical boron reagent for forming carbon-carbon bonds between aromatic systems, a fundamental step in medicinal chemistry.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific fluorinated aromatic structures.
• Materials Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, where its conjugated system and protecting groups allow for precise molecular engineering.
• Chemical Biology & Probe Development: Utilized as a tagged precursor for creating molecular probes and bioconjugates due to its reactive boronate ester functionality.
• Process Chemistry & Scale-up: Suitable for use in route development and optimization from milligram to kilogram scale for commercial production.

Basic Information

Product Name	1,3,2-Dioxaborolane, 2-[7-Fluoro-8-[2-[Tris(1-Methylethyl)Silyl]Ethynyl]-1-Naphthalenyl]-4,4,5,5-Tetramethyl-
CAS No.	2503307-87-5
Molecular Formula	C27H38BFO2Si
Molecular Weight	452.49 g/mol
Synonyms	2-(7-Fluoro-8-((triisopropylsilyl)ethynyl)naphthalen-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 7-Fluoro-8-[(triisopropylsilyl)ethynyl]-1-naphthaleneboronic acid pinacol ester; 1-Naphthaleneboronic acid, 7-fluoro-8-[2-[tris(1-methylethyl)silyl]ethynyl]-, 4,4,5,5-tetramethyl-1,3,2-dioxaborolane ester; Pinacol ester of 7-fluoro-8-(triisopropylsilylethynyl)-1-naphthaleneboronic acid; TIPS-Ethynyl Fluoronaphthalene Pinacol Boronate Ester; Fluoronaphthyl Boronic Ester with TIPS-Protected Alkyne
EINECS	Contact for details

Quality Control

This high-value synthetic intermediate is produced under strict quality control protocols to ensure batch-to-batch consistency and reliability for sensitive cross-coupling reactions. Our products undergo rigorous analytical testing, including HPLC, NMR (1H, 13C, 19F, 11B), and GC/MS, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The container should be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term stability to prevent degradation of the boronate ester functionality. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥95.0% (Area %)
Purity (NMR)	≥95.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.