Description

n-[3-(2-Methoxyethoxy)Propyl]-5-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Amine is a high-value, advanced pharmaceutical intermediate featuring a pyridine core functionalized with a protected boronic ester and an amine-linked polyether chain. This compound is specifically engineered for use in sophisticated cross-coupling reactions, such as the Suzuki-Miyaura reaction, which are fundamental to modern medicinal chemistry and drug discovery. It is an essential building block for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) for oncology, neurology, and antiviral therapies.
• Suzuki-Miyaura Cross-Coupling Reagent: The tetramethyl-1,3,2-dioxaborolane (pinacol boronic ester) group enables efficient, palladium-catalyzed carbon-carbon bond formation with aryl/heteroaryl halides.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring complex heterocyclic structures.
• Ligand and Catalyst Development: The pyridin-2-amine moiety can act as a coordinating ligand for metal complexes used in catalysis.
• Materials Science Research: Serves as a functional monomer or building block for creating organic electronic materials, polymers, and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	n-[3-(2-Methoxyethoxy)Propyl]-5-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Amine
CAS No.	2490665-96-6
Molecular Formula	C17H29BN2O4
Molecular Weight	336.24 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-[3-(2-methoxyethoxy)propyl]pyridin-2-amine; 2-Amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-[3-(2-methoxyethoxy)propyl]pyridine; 5-Pinacolboryl-N-[3-(2-methoxyethoxy)propyl]pyridin-2-amine; 2490665-96-6; 5-(Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-[3-(2-methoxyethoxy)propyl]pyridin-2-amine; Boronic ester pyridine derivative; 2-Pyridinamine, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-[3-(2-methoxyethoxy)propyl]-
EINECS	Contact for details

Quality Control

Our production of n-[3-(2-Methoxyethoxy)Propyl]-5-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Amine adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for critical research and manufacturing applications. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.