Description

6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Chroman-2-One is a high-purity, advanced pharmaceutical intermediate featuring a chromanone core functionalized with a pinacol boronate ester group. This compound is of significant value in modern organic synthesis, particularly for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of complex molecules in drug discovery and development pipelines.
• Suzuki-Miyaura Cross-Coupling Reagent: Utilized as a versatile boronic ester partner for palladium-catalyzed coupling with aryl/heteroaryl halides.
• Agrochemical Research: Serves as a precursor in the design and synthesis of new crop protection agents and herbicides.
• Material Science: Used in the creation of organic electronic materials, ligands, and polymers requiring specific chromanone architectures.
• Chemical Biology Probes: Employed in the development of molecular probes and inhibitors for biological target validation.
• Academic & Process Chemistry: A valuable reagent for methodological studies and scalable process optimization in synthetic chemistry.

Basic Information

Product Name	6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Chroman-2-One
CAS No.	2484920-14-9
Molecular Formula	C15H19BO4
Molecular Weight	274.12 g/mol
Synonyms	6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-chromen-2-one; 6-(Pinacolboryl)chroman-2-one; 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)chroman-2-one; 2-Oxo-2H-chromene-6-boronic acid pinacol ester; 6-Boronochroman-2-one pinacol ester; Chroman-2-one, 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
EINECS	Contact for details

Quality Control

Our production of 6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Chroman-2-One adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and supporting regulatory documentation for research and development purposes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and may require storage under an inert atmosphere for long-term preservation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.