Description

1,3,2-Dioxaborolane, 2-[3,4-Dihydro-6-(Phenylmethoxy)-2-Naphthalenyl]-4,4,5,5-Tetramethyl- is a high-value, advanced pharmaceutical intermediate belonging to the class of pinacol boronic esters. This compound matters as a critical building block in modern synthetic chemistry, enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of complex organic molecules and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a stable organoboron reagent for palladium-catalyzed coupling with aryl/vinyl halides to construct biaryl structures.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides requiring specific aromatic frameworks.
• Material Science Research: Employed in the development of organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors.
• Chemical Biology & Proteomics: Acts as a versatile handle for bioconjugation and labeling strategies in probe development.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and process development.

Basic Information

Product Name	1,3,2-Dioxaborolane, 2-[3,4-Dihydro-6-(Phenylmethoxy)-2-Naphthalenyl]-4,4,5,5-Tetramethyl-
CAS No.	2477812-43-2
Molecular Formula	C23H27BO3
Molecular Weight	362.27 g/mol
Synonyms	2-(6-(Benzyloxy)-3,4-dihydronaphthalen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (6-(Benzyloxy)-3,4-dihydronaphthalen-2-yl)boronic acid pinacol ester; 6-(Benzyloxy)-3,4-dihydronaphthalene-2-boronic acid pinacol ester; Pinacol [6-(benzyloxy)-3,4-dihydronaphthalen-2-yl]boronate; B-[6-(Phenylmethoxy)-3,4-dihydro-2-naphthalenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 1,3,2-Dioxaborolane derivative is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with exacting customer specifications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when possible to maintain stability and prevent hydrolysis. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.