Description

1,3,2-Dioxaborolane, 2-(7,8-Difluoro-1-Naphthalenyl)-4,4,5,5-Tetramethyl- is a high-purity, advanced boronic ester derivative, serving as a critical synthetic intermediate in modern organic chemistry. Its value lies in enabling precise carbon-carbon bond formation, a cornerstone reaction for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients through Suzuki-Miyaura cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, especially those containing difluorinated naphthalene scaffolds for oncology and CNS-targeted therapies.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides requiring specific fluorinated aromatic structures.
• Material Science Research: Employed in the creation of organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge transport materials, where its boronate ester group facilitates polymerization or functionalization.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands and organometallic catalysts used in asymmetric synthesis and other catalytic processes.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological processes and protein interactions.
• Custom Synthesis and Contract Manufacturing: A vital reagent for custom synthesis houses and CROs (Contract Research Organizations) serving the global life sciences sector.

Basic Information

Product Name	1,3,2-Dioxaborolane, 2-(7,8-Difluoro-1-Naphthalenyl)-4,4,5,5-Tetramethyl-
CAS No.	2454490-85-6
Molecular Formula	C₁₈H₂₀BFO₂
Molecular Weight	298.16 g/mol
Synonyms	2-(7,8-Difluoronaphthalen-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (7,8-Difluoronaphthalen-1-yl)boronic acid pinacol ester; 1-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-7,8-difluoronaphthalene; 7,8-Difluoro-1-naphthaleneboronic acid pinacol ester; Pinacol (7,8-difluoro-1-naphthyl)boronate; 1-(7,8-Difluoro)naphthylboronic acid pinacol ester; Naphthalene-1-boronic acid, 7,8-difluoro-, 1,1-dimethylethyl ester (pinacol ester)
EINECS	Contact for details

Quality Control

Our 1,3,2-Dioxaborolane, 2-(7,8-Difluoro-1-Naphthalenyl)-4,4,5,5-Tetramethyl- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and MS, to ensure it meets the high standards required for sensitive cross-coupling reactions. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic nature. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.