Description

n-Butyl-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzamide is a high-value, advanced pharmaceutical intermediate featuring a benzamide core functionalized with a pinacol boronate ester group. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern synthetic chemistry for constructing complex carbon-carbon bonds. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of novel active pharmaceutical ingredients (APIs), agrochemicals, and organic electronic materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those requiring biaryl or heterobiaryl motifs.
• Suzuki-Miyaura Cross-Coupling Reagent: Serves as a versatile organoboron coupling partner for the palladium-catalyzed formation of C-C bonds with aryl or vinyl halides.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that incorporate functionalized benzamide structures.
• Material Science: Employed in the synthesis of organic semiconductors, ligands for catalysts, and advanced polymers.
• Chemical Biology & Proteomics: Can be utilized as a precursor for bioconjugation reagents or activity-based probes.
• Academic & Process R&D: Essential for methodological studies and scaling up synthetic routes in both academic and industrial laboratory settings.

Basic Information

Item	Details
Product Name	n-Butyl-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzamide
CAS No.	2451465-21-5
Molecular Formula	C₁₇H₂₆BNO₃
Molecular Weight	303.21 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-butylbenzamide; N-Butyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide; 4-Pinacolatoboron-N-butylbenzamide; 4-Boronic acid pinacol ester, N-butylbenzamide derivative; (4-(Butylcarbamoyl)phenyl)boronic acid pinacol ester; B-[4-[(Butylamino)carbonyl]phenyl]boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our n-Butyl-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzamide is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing including HPLC for purity and identity confirmation via NMR and MS. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or cGMP-grade requirements. Specifications can be tailored to meet specific project needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.