Description

1H-Benzimidazole, 2-Ethyl-1-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl] is a high-purity, advanced pharmaceutical intermediate featuring a benzimidazole core linked to a pinacol boronate ester functional group. This compound matters as a critical building block in modern medicinal chemistry, enabling key carbon-carbon bond-forming reactions like the Suzuki-Miyaura cross-coupling. It is primarily needed by research institutions and pharmaceutical companies engaged in the discovery and development of novel therapeutic agents, particularly for oncology and antiviral applications.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates targeting various disease pathways.
• Suzuki-Miyaura Cross-Coupling Reagent: The boronate ester group serves as a versatile handle for palladium-catalyzed coupling with aryl/heteroaryl halides, enabling efficient construction of complex biaryl structures.
• Chemical Biology & Proteomics: Used in the development of chemical probes and affinity tags for studying protein function and interactions.
• Material Science Research: Employed as a monomer or building block for creating novel organic electronic materials and polymers with specific optoelectronic properties.
• Agrochemical Synthesis: Intermediate in the research and development of new crop protection agents and herbicides.

Basic Information

Product Name	1H-Benzimidazole, 2-Ethyl-1-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]
CAS No.	2415827-15-3
Molecular Formula	C21H25BN2O2
Molecular Weight	348.25 g/mol
Synonyms	2-Ethyl-1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1H-benzimidazole; 1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-2-ethyl-1H-benzimidazole; 2-Ethyl-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1H-benzo[d]imidazole; 1-(4-Pinacolatoboronphenyl)-2-ethylbenzimidazole; 2-Ethyl-1-(4-(pinacolatoboryl)phenyl)-1H-benzimidazole; Boronic acid, B-[4-(2-ethyl-1H-benzimidazol-1-yl)phenyl]-, pinacol ester
EINECS	Contact for details

Quality Control

Our 1H-Benzimidazole, 2-Ethyl-1-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl] is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.