Description

tert-Butyl 6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-Azaspiro[3.4]Oct-6-Ene-2-Carboxylate is a sophisticated, high-value pharmaceutical intermediate featuring a unique spirocyclic scaffold and a pinacol boronate ester functional group. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern medicinal chemistry for constructing complex carbon-carbon bonds. It is primarily utilized by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in oncology, CNS, and anti-infective research.
• Medicinal Chemistry R&D: Enables late-stage functionalization and diversification of molecular scaffolds via efficient Suzuki-Miyaura cross-coupling.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides requiring complex, boron-containing intermediates.
• Chemical Biology Probes: Serves as a precursor for creating labeled compounds or probes used in target identification and validation studies.
• Material Science Research: Potential intermediate for the development of organic electronic materials or metal-organic frameworks (MOFs).
• Process Chemistry Development: Employed in route scouting and optimization for scalable manufacturing of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	tert-Butyl 6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-Azaspiro[3.4]Oct-6-Ene-2-Carboxylate
CAS No.	2411223-34-0
Molecular Formula	C21H34BNO4
Molecular Weight	375.31 g/mol
Synonyms	2-Azaspiro[3.4]oct-6-ene-2-carboxylic acid, 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, 1,1-dimethylethyl ester; tert-Butyl 6-(pinacolatoboryl)-2-azaspiro[3.4]oct-6-ene-2-carboxylate; 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-azaspiro[3.4]oct-6-ene-2-carboxylic acid tert-butyl ester; 2-Boc-2-azaspiro[3.4]oct-6-ene-6-boronic acid pinacol ester; CAS 2411223-34-0
EINECS	Contact for details

Quality Control

Our tert-Butyl 6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-Azaspiro[3.4]Oct-6-Ene-2-Carboxylate is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and MS, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with full analytical data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive and light-sensitive nature. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.