Description

1,3,2-Dioxaborolane, 4,4,5,5-Tetramethyl-2-[3-(Trifluoromethyl)Bicyclo[1.1.1]Pent-1-Yl]- is a highly specialized organoboron reagent featuring a unique, rigid bicyclo[1.1.1]pentane (BCP) scaffold. This compound matters for its role as a critical building block in modern pharmaceutical and agrochemical research, enabling the direct introduction of the BCP motif, a valuable isostere for a para-substituted benzene ring or a tert-butyl group. Researchers and process chemists in life sciences need it to develop new drug candidates with improved metabolic stability, solubility, and physicochemical properties.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: As a key boron reagent for introducing the 3-(trifluoromethyl)bicyclo[1.1.1]pent-1-yl group into complex molecules.
• Pharmaceutical Intermediate: Synthesis of active pharmaceutical ingredients (APIs) targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Development: Creation of novel herbicides and fungicides with enhanced efficacy and environmental profiles.
• Materials Science Research: Incorporation into organic frameworks and polymers to tune electronic properties and structural rigidity.
• PET Ligand Synthesis: Potential use in developing radiotracers for positron emission tomography (PET) imaging.
• Medicinal Chemistry: A versatile building block for constructing bioisosteres in structure-activity relationship (SAR) studies.

Basic Information

Item	Details
Product Name	1,3,2-Dioxaborolane, 4,4,5,5-Tetramethyl-2-[3-(Trifluoromethyl)Bicyclo[1.1.1]Pent-1-Yl]-
CAS No.	2410440-14-9
Molecular Formula	C12H18BF3O2
Molecular Weight	262.08 g/mol
Synonyms	2-[3-(Trifluoromethyl)bicyclo[1.1.1]pentan-1-yl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-(Trifluoromethyl)bicyclo[1.1.1]pentane-1-boronic acid pinacol ester; 1-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethyl)bicyclo[1.1.1]pentane; BCP-BPin (TFM); [3-(Trifluoromethyl)bicyclo[1.1.1]pent-1-yl]boronic acid pinacol ester; (3-(Trifluoromethyl)bicyclo[1.1.1]pent-1-yl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 1,3,2-Dioxaborolane, 4,4,5,5-Tetramethyl-2-[3-(Trifluoromethyl)Bicyclo[1.1.1]Pent-1-Yl]- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR (¹H, ¹³C, ¹¹B) and HPLC analysis, to ensure high chemical purity and identity. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to handle and store the product under an inert atmosphere (e.g., nitrogen or argon) to maintain stability and purity. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.