Description

Benzo[B]Thiophen-2-Amine, 4-(Trifluoromethyl)- is a high-value, fluorinated heterocyclic amine building block. This compound matters for its role as a critical intermediate in the synthesis of advanced pharmaceuticals and agrochemicals, where the trifluoromethyl group is prized for its ability to modulate lipophilicity, metabolic stability, and bioavailability. It is primarily needed by R&D chemists and process development scientists in pharmaceutical, agrochemical, and advanced material industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel drug candidates, particularly in kinase inhibitors, antiviral agents, and central nervous system (CNS) therapeutics.
• Agrochemical Synthesis: Building block for next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Material Science Research: Precursor for organic electronic materials, such as organic semiconductors and light-emitting diodes (OLEDs), due to its conjugated thiophene-amine structure.
• Ligand and Catalyst Development: Used in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry Studies: A valuable substrate for exploring new fluorination reactions and studying structure-activity relationships (SAR) in medicinal chemistry.

Basic Information

Product Name	Benzo[B]Thiophen-2-Amine, 4-(Trifluoromethyl)-
CAS No.	2385617-19-4
Molecular Formula	C9H6F3NS
Molecular Weight	217.21 g/mol
Synonyms	4-(Trifluoromethyl)-1-benzothiophen-2-amine; 4-(Trifluoromethyl)benzo[b]thiophen-2-amine; 2-Amino-4-(trifluoromethyl)benzo[b]thiophene; 4-Trifluoromethylbenzo[b]thiophen-2-ylamine; 4-CF3-BTA
EINECS	Contact for details

Quality Control

Our Benzo[B]Thiophen-2-Amine, 4-(Trifluoromethyl)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.