Description

1-Methyl-Piperidine-4-Boronic Acid Picol Ester Hydrochloride is a high-value, protected boronic acid derivative used as a key synthetic intermediate in advanced organic chemistry. Its primary value lies in its role as a versatile building block for constructing complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on new active pharmaceutical ingredients (APIs), especially within the fields of oncology and central nervous system (CNS) therapeutics.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly for targeted therapies.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a protected boronic ester reagent for forming carbon-carbon bonds under mild conditions, essential for constructing biaryl and heterobiaryl scaffolds.
• Medicinal Chemistry & Lead Optimization: Used in parallel and combinatorial synthesis to rapidly generate libraries of compounds for biological screening.
• Process Chemistry & Scale-Up: Employed in the development of robust, scalable synthetic routes for potential commercial APIs.
• Agrochemical Research: Utilized in the discovery of new active ingredients with specific biological activity.
• Material Science: Potential building block for creating novel organic electronic materials or metal-organic frameworks (MOFs).

Basic Information

Product Name	1-Methyl-Piperidine-4-Boronic Acid Picol Ester Hydrochloride
CAS No.	2379560-96-8
Molecular Formula	C12H18BClN2O2
Molecular Weight	268.55 g/mol
Synonyms	1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)piperidine Hydrochloride; 1-Methylpiperidine-4-boronic acid pinacol ester hydrochloride; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-methylpiperidine hydrochloride; 1-Methyl-4-(pinacolboronato)piperidine HCl; N-Methyl-4-(pinacolatoboryl)piperidine hydrochloride; 1-Methyl-4-(pinacolatoboryl)piperidinium chloride
EINECS	Contact for details

Quality Control

Our 1-Methyl-Piperidine-4-Boronic Acid Picol Ester Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.