Description

6-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-1H-Indazole-3-Carboxylic Acid Methyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a pinacol boronate ester group, which is critical for modern cross-coupling reactions in medicinal chemistry. This compound is essential for the efficient synthesis of complex heterocyclic scaffolds, enabling the rapid exploration of structure-activity relationships in drug discovery programs. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel small-molecule therapeutics, particularly in oncology and CNS disease areas.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a key boron-containing building block for the synthesis of biaryl and heterobiaryl structures in active pharmaceutical ingredients (APIs).
• Medicinal Chemistry & Drug Discovery: Used as a versatile intermediate for the construction and diversification of indazole-based compound libraries for high-throughput screening and lead optimization.
• Process Chemistry & API Development: Employed in route scouting and scale-up synthesis for the production of candidate drugs, leveraging its stability and reactivity.
• Chemical Biology & Probe Development: Facilitates the creation of molecular probes and tools for studying biological pathways and target engagement.
• Contract Research & Manufacturing (CRO/CMO): A critical raw material for organizations providing custom synthesis and process development services to the biopharma industry.

Basic Information

Product Name	6-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-1H-Indazole-3-Carboxylic Acid Methyl Ester
CAS No.	2379560-87-7
Molecular Formula	C15H19BN2O4
Molecular Weight	302.14 g/mol
Synonyms	Methyl 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-3-carboxylate; 6-(Pinacolboryl)-1H-indazole-3-carboxylic acid methyl ester; 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-3-carboxylic acid methyl ester; 1H-Indazole-3-carboxylic acid, 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, methyl ester; CAS 2379560-87-7
EINECS	Contact for details

Quality Control

Our production of 6-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-1H-Indazole-3-Carboxylic Acid Methyl Ester adheres to stringent quality management systems, ensuring batch-to-batch consistency for critical research and development applications. All material is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with cGMP and ISO 9001 standards for pharmaceutical intermediates, and specifications can be aligned with client-specific requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (HPLC, Area%)	≥98.0%
Single Maximum Impurity	≤1.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.