Description

2-(1,3,2-Dioxaborinan-2-Yl)Benzamide is a high-purity, advanced pharmaceutical intermediate featuring a benzamide core integrated with a cyclic dioxaborinane moiety. This compound is of significant value for medicinal chemistry research and development, serving as a key building block in the synthesis of novel bioactive molecules, particularly in the field of boron-containing therapeutics. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to leverage boron's unique properties for drug discovery.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of Boron-containing Drug Candidates, especially for Boron Neutron Capture Therapy (BNCT) agents and protease inhibitors.
• Medicinal Chemistry Research: Used as a versatile building block for constructing complex molecular libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Agrochemical Development: Employed in the research and synthesis of novel herbicides and pesticides that incorporate boron for enhanced bioactivity.
• Chemical Biology Probes: Serves as a starting material for developing activity-based probes and diagnostic agents that target specific enzymes or biological pathways.
• Organic Synthesis Reagent: Utilized in Suzuki-Miyaura and other palladium-catalyzed cross-coupling reactions as a protected boronic ester equivalent.
• Material Science Research: Investigated as a monomer or additive for creating novel polymers and organic electronic materials with specific optical or electronic properties.

Basic Information

Product Name	2-(1,3,2-Dioxaborinan-2-Yl)Benzamide
CAS No.	2377611-18-0
Molecular Formula	C11H14BNO3
Molecular Weight	219.05 g/mol
Synonyms	Benzamide, 2-(1,3,2-dioxaborinan-2-yl)-; 2-(1,3,2-Dioxaborinan-2-yl)benzamide; 2-(1,3,2-Dioxaborinan-2-Yl)benzoic acid amide; 2-(2-Boranyl-1,3,2λ³-dioxaborinan-2-yl)benzamide; 2-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)benzamide (related structure); o-(1,3,2-Dioxaborinan-2-yl)benzamide; B-Protected Benzamide Boronic Ester
EINECS	Contact for details

Quality Control

Our 2-(1,3,2-Dioxaborinan-2-Yl)Benzamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, impurity profiles, and other critical parameters. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring traceability and consistency for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under a dry inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. For long-term storage, consider storing under an inert gas blanket in a desiccator.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.