Description

Benzyl N-[4-Fluoro-3-(Tetramethyl-1,3,2-Dioxaborolan-2-yl)Phenyl]Carbamate is a high-purity, advanced pharmaceutical intermediate featuring a protected boronic ester group. This compound is critical for enabling efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, which are fundamental to modern medicinal chemistry and drug discovery. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of novel, complex organic molecules, particularly for developing targeted therapies and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a crucial boron-containing coupling partner for forming carbon-carbon bonds in complex molecule assembly.
• Medicinal Chemistry & Drug Discovery: Used in research labs for constructing molecular libraries and optimizing lead compounds for biological activity.
• Agrochemical Synthesis: Employed in the research and development of novel pesticides and herbicides requiring specific fluorinated and boronate motifs.
• Material Science Research: Potential precursor for creating organic electronic materials or metal-organic frameworks (MOFs) with specific functional properties.
• Process Chemistry & Scale-Up: Suitable for use in developing and optimizing scalable synthetic routes from laboratory to pilot plant scale.

Basic Information

Product Name	Benzyl N-[4-Fluoro-3-(Tetramethyl-1,3,2-Dioxaborolan-2-yl)Phenyl]Carbamate
CAS No.	2377610-77-8
Molecular Formula	C20H23BFNO4
Molecular Weight	371.21 g/mol
Synonyms	Benzyl (4-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)carbamate; Carbamic acid, N-[4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-, phenylmethyl ester; 4-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline, N-Cbz protected; N-Cbz-4-Fluoro-3-(pinacolboronate)aniline; Benzyl 4-Fluoro-3-(pinacolboronato)carbanilate; 2377610-77-8; Bz-4F-3-PinB-Aniline Carbamate
EINECS	Contact for details

Quality Control

Our Benzyl N-[4-Fluoro-3-(Tetramethyl-1,3,2-Dioxaborolan-2-yl)Phenyl]Carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under an inert atmosphere when appropriate for prolonged use to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.