Description

3-(4-Methoxy-Benzyloxy)-5-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Benzonitrile is a high-purity, advanced pharmaceutical intermediate featuring a pinacol boronate ester group, a critical functional handle for modern synthetic transformations. This compound matters as a key building block in the synthesis of complex molecules, enabling efficient carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly in oncology and CNS therapeutic areas.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the efficient formation of carbon-carbon bonds for constructing complex biaryl and heterobiaryl structures in medicinal chemistry.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific aryl-boronate motifs.
• Material Science Research: Serves as a monomer or precursor for developing organic electronic materials, such as OLEDs and organic semiconductors.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Utilized as a linker or functional component in the design of bifunctional molecules for targeted protein degradation.
• Academic & Contract Research: A valuable reagent for methodology development and synthetic chemistry research in university and CRO laboratories.

Basic Information

Item	Details
Product Name	3-(4-Methoxy-Benzyloxy)-5-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Benzonitrile
CAS No.	2377609-88-4
Molecular Formula	C21H24BNO4
Molecular Weight	365.23 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-[(4-methoxyphenyl)methoxy]benzonitrile; 3-[(4-Methoxybenzyl)oxy]-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile; 3-(4-Methoxybenzyloxy)-5-(pinacolboryl)benzonitrile; 5-(Pinacolboranyl)-3-(4-methoxybenzyloxy)benzonitrile; Boronic acid, B-[3-cyano-5-[(4-methoxyphenyl)methoxy]phenyl]-, pinacol ester; 2377609-88-4; 3-(4-Methoxybenzyloxy)-5-(pinacolato)borylbenzonitrile
EINECS	Contact for details

Quality Control

Our 3-(4-Methoxy-Benzyloxy)-5-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Benzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity suitable for demanding synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability. Keep the container tightly sealed when not in use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.