Description

1-Boc-6-(Methoxycarbonyl)Indole-3-Boronic Acid Pinacol Ester is a sophisticated, multi-functional indole derivative designed for advanced organic synthesis. This compound is a critical protected building block that enables the precise construction of complex molecular architectures, particularly in pharmaceutical research. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the development of novel active ingredients.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a key boronic ester component for the palladium-catalyzed formation of carbon-carbon bonds, enabling the introduction of the indole scaffold into complex molecules.
• Pharmaceutical Intermediate: A vital precursor in the synthesis of drug candidates targeting a wide range of therapeutic areas, including oncology, CNS disorders, and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, where the indole core is a common bioactive motif.
• Material Science & OLED Development: Functions as a building block for creating organic semiconductors and light-emitting materials used in electronic displays.
• Chemical Biology & Probe Development: Employed in the creation of molecular probes and labeled compounds for studying biological pathways and target engagement.
• Library Synthesis for High-Throughput Screening: Enables the rapid generation of diverse compound libraries to identify new lead structures in drug discovery campaigns.

Basic Information

Product Name	1-Boc-6-(Methoxycarbonyl)Indole-3-Boronic Acid Pinacol Ester
CAS No.	2377609-81-7
Molecular Formula	C21H28BNO6
Molecular Weight	401.26 g/mol
Synonyms	1-Boc-6-(Methoxycarbonyl)indole-3-boronic acid pinacol ester; 6-(Methoxycarbonyl)-1-[(tert-butoxy)carbonyl]-1H-indole-3-boronic acid pinacol ester; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1,6-dicarboxylic acid 1-tert-butyl ester 6-methyl ester; tert-Butyl 6-(methoxycarbonyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylate; 1-Boc-6-COOMe-indole-3-Bpin
EINECS	Contact for details

Quality Control

Our production of 1-Boc-6-(Methoxycarbonyl)Indole-3-Boronic Acid Pinacol Ester adheres to stringent quality protocols suitable for research and development applications. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and lot-to-lot consistency. Certificates of Analysis (COA) detailing specifications such as HPLC purity, NMR confirmation, and moisture content are provided with every shipment. We support our clients' regulatory needs with full traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95.0% (Area %)
Water Content (KF)	≤1.0%
Solubility	Soluble in common organic solvents (DMSO, DMF, THF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.