Description

2-(Ethoxycarbonyl)-1-Benzothiophene-4-Boronic Acid, Pinacol Ester is a high-purity, advanced pharmaceutical intermediate belonging to the class of protected boronic acid derivatives. This compound is a critical building block in modern synthetic chemistry, enabling the precise construction of complex molecules through cross-coupling reactions. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for constructing carbon-carbon bonds in drug discovery and development, particularly for creating novel benzothiophene-based scaffolds.
• Agrochemical Synthesis: Used in the research and production of advanced crop protection agents and herbicides that require specific heterocyclic architectures.
• Material Science Research: Serves as a monomer or functional unit in the development of organic electronic materials, such as organic semiconductors and light-emitting diodes (OLEDs).
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and labeled compounds for biochemical assays and diagnostic research.
• Process Chemistry & Scale-up: Provides a stable, storable boronate source for optimizing and scaling up synthetic routes in pilot plants and commercial manufacturing.

Basic Information

Product Name	2-(Ethoxycarbonyl)-1-Benzothiophene-4-Boronic Acid, Pinacol Ester
CAS No.	2377609-47-5
Molecular Formula	C17H21BO4S
Molecular Weight	332.22 g/mol
Synonyms	4,4,5,5-Tetramethyl-2-[2-(ethoxycarbonyl)benzothiophen-4-yl]-1,3,2-dioxaborolane; 2-(Ethoxycarbonyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-benzothiophene; Ethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-benzothiophene-2-carboxylate; 1-Benzothiophene-2-carboxylic acid, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, ethyl ester; Benzothiophene boronic ester pinacol; CAS 2377609-47-5.
EINECS	Contact for details

Quality Control

Our 2-(Ethoxycarbonyl)-1-Benzothiophene-4-Boronic Acid, Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.