Description

5-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)-1,3,4-Thiadiazol-2-Amine is a high-value, multi-functional heterocyclic building block that combines a 1,3,4-thiadiazole core with a pinacol boronate ester. This compound is essential for modern synthetic chemistry, enabling the precise construction of complex molecular architectures. It is primarily sought after by researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries for applications in drug discovery, catalyst development, and advanced polymer synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used to create advanced active ingredients for crop protection agents, leveraging the bioactivity of the thiadiazole moiety.
• Materials Science: Serves as a monomer or functional additive in the development of organic electronic materials, such as OLEDs and conductive polymers.
• Chemical Biology: Employed as a probe or linker in bioconjugation and proteomics studies due to its reactive amine and boronate groups.
• Catalyst Ligand Development: The unique structure can be utilized to design novel ligands for transition metal catalysis.
• Academic & Contract Research: A valuable reagent for method development and exploring new synthetic pathways in organic chemistry laboratories.

Basic Information

Product Name	5-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)-1,3,4-Thiadiazol-2-Amine
CAS No.	2377609-43-1
Molecular Formula	C14H19BN3O2S
Molecular Weight	304.20 g/mol
Synonyms	2-Amino-5-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1,3,4-thiadiazole; 5-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-2-amino-1,3,4-thiadiazole; 4-(2-Amino-1,3,4-thiadiazol-5-yl)phenylboronic acid pinacol ester; 5-(4-Bpin-phenyl)-1,3,4-thiadiazol-2-amine; B-(4-(2-Amino-1,3,4-thiadiazol-5-yl)phenyl)boronic acid pinacol ester; 2377609-43-1; 5-(4-Boronophenyl)-1,3,4-thiadiazol-2-amine pinacol ester
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Quality Control

Our 5-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)-1,3,4-Thiadiazol-2-Amine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and structural integrity. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your R&D and quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.