Description

Benzyl 5-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine-2-Carboxylate is a high-purity boronic ester derivative, a crucial building block in modern synthetic organic chemistry. Its core value lies in enabling efficient, selective cross-coupling reactions, which are fundamental for constructing complex molecular architectures. This advanced intermediate is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers for the synthesis of active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in kinase inhibitor and oncology research.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides where the pyridine-boronate moiety is integral to biological activity.
• Material Science Research: Serves as a monomer or functionalizing agent in the creation of organic electronic materials, such as OLEDs and conductive polymers.
• Ligand and Catalyst Development: Employed in the synthesis of novel bidentate ligands for transition metal catalysis.
• Chemical Biology Probes: Utilized for labeling and modifying biomolecules due to its bioorthogonal reactivity profile.
• Academic & Contract Research: Essential for methodological development and library synthesis in academic and CRO (Contract Research Organization) laboratories.

Basic Information

Product Name	Benzyl 5-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine-2-Carboxylate
CAS No.	2377608-16-5
Molecular Formula	C20H24BNO4
Molecular Weight	353.22 g/mol
Synonyms	Benzyl 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)picolinate; 2-Pyridinecarboxylic acid, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, benzyl ester; 5-(Tetramethyl-1,3,2-dioxaborolan-2-yl)picolinic acid benzyl ester; Benzyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinecarboxylate; CAS 2377608-16-5
EINECS	Contact for details

Quality Control

Our Benzyl 5-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and prevent hydrolysis of the boronic ester moiety.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.