Description

Benzyl N-[2,3-Difluoro-5-(Tetramethyl-1,3,2-Dioxaborolan-2-yl)Phenyl]Carbamate is a high-purity, advanced pharmaceutical intermediate featuring a protected boronic ester functional group. This compound is specifically engineered for use in Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl scaffolds. It is an essential building block for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries developing novel active ingredients and functional molecules.

Application

• Key Intermediate in API Synthesis: Serves as a critical precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly those containing fluorinated biaryl motifs.
• Suzuki-Miyaura Cross-Coupling Reagent: The tetramethyl dioxaborolane (pinacol boronic ester) group acts as a stable, protected handle for efficient palladium-catalyzed carbon-carbon bond formation with aryl halides.
• Medicinal Chemistry & Drug Discovery: Enables the rapid exploration of structure-activity relationships (SAR) by facilitating the introduction of difluorophenyl-carbamate fragments into candidate molecules.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides where the specific fluorinated aromatic structure can enhance bioactivity and stability.
• Ligand and Catalyst Development: Can be utilized to synthesize novel chelating ligands or as a substrate in catalyst screening and optimization studies.
• Material Science Precursor: Potential building block for creating specialty polymers or organic electronic materials with tailored properties.

Basic Information

Item	Details
Product Name	Benzyl N-[2,3-Difluoro-5-(Tetramethyl-1,3,2-Dioxaborolan-2-yl)Phenyl]Carbamate
CAS No.	2377607-45-7
Molecular Formula	C20H22BF2NO4
Molecular Weight	389.20 g/mol
Synonyms	Benzyl (2,3-difluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)carbamate; 2,3-Difluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl benzylcarbamate; N-Benzyloxycarbonyl-2,3-difluoro-5-(pinacolboron)aniline; 5-(Benzyloxycarbonylamino)-2,3-difluorophenylboronic acid pinacol ester; 2,3-Difluoro-5-((((benzyloxy)carbonyl)amino)phenyl)boronic acid pinacol ester; Benzyl N-[2,3-difluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]carbamate
EINECS	Contact for details

Quality Control

Our Benzyl N-[2,3-Difluoro-5-(Tetramethyl-1,3,2-Dioxaborolan-2-yl)Phenyl]Carbamate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, NMR, and other relevant techniques. Our quality commitment supports applications requiring GMP-grade intermediates and reliable supply for critical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0% (Area Percent)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.