Description

tert-Butyl 4-Fluoro-2-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoate is a high-purity, synthetically valuable boronic ester derivative. This compound serves as a critical advanced pharmaceutical intermediate and versatile building block in modern organic synthesis. It is primarily utilized by R&D chemists and process development teams in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds, essential in synthesizing complex biaryl structures found in active pharmaceutical ingredients (APIs).
• Pharmaceutical Intermediate: Used in the research and development of novel drug candidates, particularly in oncology, CNS, and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Serves as a building block for creating advanced herbicides, fungicides, and insecticides with improved efficacy.
• Material Science & OLED Development: Employed in the synthesis of organic semiconductors, liquid crystals, and light-emitting materials for electronic displays.
• Chemical Biology & Proteomics: Utilized in the development of molecular probes and activity-based protein profiling (ABPP) reagents.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring specific fluorinated and boronate-functionalized motifs.

Basic Information

Product Name	tert-Butyl 4-Fluoro-2-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoate
CAS No.	2377607-40-2
Molecular Formula	C₁₇H₂₄BFO₄
Molecular Weight	322.18 g/mol
Synonyms	4-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid tert-butyl ester; 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-fluorobenzoic acid tert-butyl ester; tert-Butyl 4-fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate; 4-Fluoro-2-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid 1,1-dimethylethyl ester; Pinacol (4-(tert-butoxycarbonyl)-3-fluorophenyl)boronate; (4-(tert-Butoxycarbonyl)-3-fluorophenyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-Fluoro-2-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR (¹H, ¹³C, ¹⁹F, ¹¹B), and GC/MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.