Description

3-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5-(Trifluoromethoxy)Phenol is a high-purity, advanced pharmaceutical intermediate featuring a phenol core substituted with a trifluoromethoxy group and a protected boronic ester moiety. This compound is critical for enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl structures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing drug candidates, particularly those requiring biaryl linkages common in kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides where the trifluoromethoxy group enhances biological activity and metabolic stability.
• Material Science: Serves as a precursor for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics, due to its conjugated phenolic system.
• Chemical Synthesis: Employed in palladium-catalyzed cross-coupling reactions to introduce the phenol-trifluoromethoxy-boronate functionality into more complex molecular architectures.
• Ligand & Catalyst Development: Acts as a starting material for synthesizing specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	3-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5-(Trifluoromethoxy)Phenol
CAS No.	2377606-48-7
Molecular Formula	C13H16BF3O4
Molecular Weight	304.07 g/mol
Synonyms	5-(Trifluoromethoxy)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol; 3-Boronic acid, 5-(trifluoromethoxy)phenol, 1,3,2-dioxaborolane ester; 2-(3-Hydroxy-5-(trifluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Phenol, 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethoxy)-; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethoxy)phenol; Trifluoromethoxy phenyl boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 3-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5-(Trifluoromethoxy)Phenol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, supporting its use in regulated research and development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive and light-sensitive nature. Allow the container to reach room temperature before opening to minimize condensation and moisture ingress. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.