Description

5-Carboxypyridine-3-Boronic Acid Pinacol Ester is a high-purity, multifunctional heterocyclic building block designed for advanced organic synthesis. This compound is valued for its dual functionality, combining a protected boronic acid group for Suzuki-Miyaura cross-coupling reactions with a carboxylic acid group for further derivatization. It is an essential intermediate for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides with specific targeting properties.
• Material Science Research: Serves as a precursor for creating functionalized polymers, ligands for catalysis, and organic electronic materials.
• Suzuki-Miyaura Cross-Coupling: The pinacol-protected boronic ester moiety enables efficient palladium-catalyzed carbon-carbon bond formation under mild conditions.
• Ligand and Catalyst Design: The pyridine and carboxylic acid groups allow for chelation to metal centers, useful in designing new catalytic systems.
• Chemical Biology Probes: Utilized in the creation of molecular probes for studying biological pathways and protein interactions.

Basic Information

Product Name	5-Carboxypyridine-3-Boronic Acid Pinacol Ester
CAS No.	2377606-46-5
Molecular Formula	C13H16BNO4
Molecular Weight	261.09 g/mol
Synonyms	3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-pyridinecarboxylic Acid; 5-Carboxy-3-pyridylboronic Acid Pinacol Ester; 5-(Carboxy)pyridin-3-ylboronic Acid Pinacol Ester; 3-Borono-5-pyridinecarboxylic Acid Pinacol Ester; Nicotinic Acid-3-Boronic Acid Pinacol Ester; 3-Pinacolatoboryl-5-pyridinecarboxylic Acid; 5-Carboxynicotin-3-ylboronic Acid Pinacol Ester
EINECS	Contact for details

Quality Control

Our 5-Carboxypyridine-3-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.