Description

2-Carboxy-5-Chlorophenylboronic Acid Pinacol Ester is a high-purity, synthetically valuable boronic ester derivative. This compound serves as a crucial protected intermediate in modern organic synthesis, particularly in cross-coupling reactions, enabling the precise construction of complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for the development of new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key building block in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially biphenyl and heterobiaryl structures.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and insecticides requiring specific chlorinated aromatic frameworks.
• Material Science Research: Employed in the creation of organic electronic materials, such as polymers and small molecules for OLEDs and OFETs, where the boronic ester group allows for modular construction.
• Chemical Biology & Proteomics: Acts as a versatile handle for bioconjugation and the synthesis of activity-based probes and molecular sensors.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and non-commercial scale-up projects.
• Academic Research: A valuable reagent for methodology development in catalysis and new synthetic route exploration within university and institutional laboratories.

Basic Information

Product Name	2-Carboxy-5-Chlorophenylboronic Acid Pinacol Ester
CAS No.	2377606-42-1
Molecular Formula	C14H18BClO4
Molecular Weight	296.55 g/mol
Synonyms	5-Chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic Acid; (5-Chloro-2-carboxyphenyl)boronic Acid Pinacol Ester; 2-Carboxy-5-chlorobenzeneboronic Acid Pinacol Ester; 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-chlorobenzoic Acid; 5-Chloro-2-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl))benzoic Acid; 2-Borono-5-chlorobenzoic Acid Pinacol Ester; 5-Chloro-2-pinacolatoborylbenzoic Acid
EINECS	Contact for details

Quality Control

Every batch of 2-Carboxy-5-Chlorophenylboronic Acid Pinacol Ester is produced and tested under a strict quality management system. Our products undergo rigorous analytical testing, including NMR, HPLC, and LC-MS, to ensure identity, purity, and consistency meet the exacting standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing all specification results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere (e.g., nitrogen or argon) when prolonged exposure to air is necessary to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.