Description

4-(1-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Ethyl)Morpholine Hydrochloride is a high-value, synthetically versatile boronic ester derivative, primarily serving as a key pharmaceutical intermediate in modern organic synthesis. Its core value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl scaffolds. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity building blocks for drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing complex biaryl structures.
• Suzuki-Miyaura Cross-Coupling Reagent: Used to form carbon-carbon bonds between aromatic rings, enabling the construction of complex molecular architectures in medicinal chemistry and material science.
• Agrochemical Synthesis: Employed in the research and development of novel herbicides, fungicides, and insecticides that require specific aryl-aryl linkages.
• Organic Light-Emitting Diode (OLED) Materials: Serves as a precursor in the synthesis of advanced organic electronic materials and emissive layers.
• Ligand and Catalyst Development: Used to create novel bidentate or tridentate ligands for transition metal catalysis.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes and target engagement.

Basic Information

Product Name	4-(1-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Ethyl)Morpholine Hydrochloride
CAS No.	2377587-53-4
Molecular Formula	C18H29BClNO3
Molecular Weight	353.69 g/mol
Synonyms	4-[1-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethyl]morpholine hydrochloride; 4-(1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethyl)morpholine HCl; Morpholine, 4-[1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethyl]-, hydrochloride (1:1); Pinacol [4-(1-morpholin-4-ylethyl)phenyl]boronate hydrochloride; 4-(1-(4-(Pinacolatoboryl)phenyl)ethyl)morpholine hydrochloride
EINECS	Contact for details

Quality Control

Our production of 4-(1-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Ethyl)Morpholine Hydrochloride adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting critical specifications such as assay purity and impurity profiles. Our commitment to cGMP principles ensures a reliable supply for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the product should be handled under an inert atmosphere (e.g., nitrogen or argon) and stored in a desiccator to prevent moisture absorption, which can affect stability and reactivity. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (HPLC, Area %)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.