Description

Benzyl n-[5-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2,3-Dihydro-1H-Inden-2-Yl]Carbamate is a high-purity, advanced pharmaceutical intermediate featuring a protected boronic ester functional group. This compound is critical for enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl structures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of novel active pharmaceutical ingredients (APIs), particularly for oncology and central nervous system (CNS) targets.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel drug candidates, especially those containing complex indane or biaryl motifs.
• Suzuki-Miyaura Cross-Coupling Reagent: The tetramethyl-1,3,2-dioxaborolan-2-yl (pinacol boronic ester) group acts as a stable, reactive handle for palladium-catalyzed carbon-carbon bond formation with aryl halides.
• Medicinal Chemistry Research: Enables rapid analog synthesis and structure-activity relationship (SAR) studies in drug discovery programs.
• Process Chemistry Development: Used in the scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs) under Good Manufacturing Practice (GMP) conditions.
• Ligand and Material Science Precursor: Can be utilized in the synthesis of specialized organic ligands or advanced organic materials.

Basic Information

Product Name	Benzyl n-[5-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2,3-Dihydro-1H-Inden-2-Yl]Carbamate
CAS No.	2377587-35-2
Molecular Formula	C24H30BNO4
Molecular Weight	407.31 g/mol
Synonyms	Benzyl (5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-inden-2-yl)carbamate; 2,3-Dihydro-1H-inden-2-amine, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, N-(phenylmethyl)carbamate; 5-(Pinacolatoboryl)-2,3-dihydro-1H-inden-2-yl Carbamic Acid Benzyl Ester; 2-(Benzyloxycarbonylamino)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indane; Benzyl 5-(Pinacolatoboran-2-yl)-2,3-dihydro-1H-inden-2-ylcarbamate; 2377587-35-2; BRN 2377587-35-2
EINECS	Contact for details

Quality Control

Our Benzyl n-[5-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2,3-Dihydro-1H-Inden-2-Yl]Carbamate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. All batches are characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent hydrolysis of the boronic ester group.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.