Description

1-Pyrrolidinecarboxylic Acid, 3-[(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Methylene]-, 1,1-Dimethylethyl Ester is a high-value, advanced pharmaceutical intermediate featuring a pinacol boronate ester moiety. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex carbon-carbon bonds. It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of drug candidates, particularly in oncology, CNS, and antiviral research programs.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the efficient and selective formation of C-C bonds with aryl or vinyl halides under mild conditions.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides with improved efficacy.
• Material Science Research: Employed in the creation of organic electronic materials, such as polymers for OLEDs or organic photovoltaics.
• Chemical Biology Probes: Serves as a precursor for bioconjugation reagents and activity-based probes for target identification.
• Process Chemistry & Scale-Up: Supports route scouting and optimization from milligram to kilogram scale for clinical trial material production.

Basic Information

Product Name	1-Pyrrolidinecarboxylic Acid, 3-[(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Methylene]-, 1,1-Dimethylethyl Ester
CAS No.	2376764-71-3
Molecular Formula	C16H28BNO4
Molecular Weight	309.21 g/mol
Synonyms	tert-Butyl 3-[(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methylene]pyrrolidine-1-carboxylate; 1-Boc-3-[(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methylene]pyrrolidine; 3-[(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)methylene]pyrrolidine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-3-[(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methylene]pyrrolidine; Boc-Protected 3-Methylenepyrrolidine Pinacol Boronate Ester
EINECS	Contact for details

Quality Control

Our 1-Pyrrolidinecarboxylic Acid, 3-[(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Methylene]-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP compliance for advanced intermediates and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and moisture-sensitive nature. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.