Description

tert-Butyl 3-((4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Methylene)Piperidine-1-Carboxylate is a high-value, protected piperidine-based boronic ester building block crucial for modern synthetic chemistry. This compound matters as a versatile intermediate that enables the introduction of a functionalized piperidine scaffold into complex molecules via cross-coupling reactions like the Suzuki-Miyaura reaction. Pharmaceutical, agrochemical, and advanced material researchers need it for the efficient synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly in medicinal chemistry for creating piperidine-containing drug candidates targeting CNS disorders, pain management, and other therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, where the piperidine moiety can contribute to biological activity.
• Suzuki-Miyaura Cross-Coupling: Serves as a critical organoboron reagent for forming carbon-carbon bonds, enabling the construction of complex, conjugated molecular architectures in a controlled manner.
• Material Science Research: Employed in the development of organic electronic materials, ligands for catalysis, and other functional organic polymers where precise structural control is required.
• Chemical Biology & Proteomics: Utilized as a molecular scaffold or linker in the design of chemical probes, activity-based protein profiling (ABPP) reagents, and bioconjugation tools.
• Academic & Contract Research: Essential reagent for synthetic methodology development and complex natural product synthesis in university and CRO laboratory settings.

Basic Information

Item	Details
Product Name	tert-Butyl 3-((4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Methylene)Piperidine-1-Carboxylate
CAS No.	2376764-47-3
Molecular Formula	C17H30BNO4
Molecular Weight	323.24 g/mol
Synonyms	1-Boc-3-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methylene)piperidine; tert-Butyl 3-[(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methylidene]piperidine-1-carboxylate; 3-((4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)methylene)piperidine-1-carboxylic acid tert-butyl ester; 1,1-Dimethylethyl 3-[(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methylidene]-1-piperidinecarboxylate; 3-Methylene-piperidine-1-carboxylic acid tert-butyl ester pinacol boronate; Boc-3-methylene-piperidine pinacol boronic ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-((4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Methylene)Piperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are available upon request. We are committed to supplying material that meets the high standards required for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from heat and open flame.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Area %)
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.