Description

5-Chloro-6-Methyl-1-(Tetrahydro-2H-Pyran-2-Yl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indazole is a high-value, advanced pharmaceutical intermediate featuring a protected indazole core and a versatile boronic ester functional group. This compound matters as a critical building block in modern medicinal chemistry, enabling efficient cross-coupling reactions for the synthesis of complex drug candidates. It is primarily needed by R&D teams and process chemists in the pharmaceutical and biotechnology industries for the development of new therapeutic agents, particularly in oncology and CNS research.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: As a key boronic ester reagent for constructing carbon-carbon bonds in API synthesis.
• Pharmaceutical Intermediate: For the research and development of novel indazole-based drug molecules.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies.
• Process Chemistry & Scale-Up: Serves as a building block for pilot-scale and commercial manufacturing of active pharmaceutical ingredients (APIs).
• Bioconjugation & Probe Development: Potential use in creating chemical probes for biological target identification and validation.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting global drug discovery pipelines.

Basic Information

Item	Detail
Product Name	5-Chloro-6-Methyl-1-(Tetrahydro-2H-Pyran-2-Yl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indazole
CAS No.	2374152-77-7
Molecular Formula	C19H26BClN2O3
Molecular Weight	376.68 g/mol
Synonyms	5-Chloro-6-methyl-1-(tetrahydro-2H-pyran-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole; 1H-Indazole, 5-chloro-6-methyl-1-(tetrahydro-2H-pyran-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-chloro-6-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole; THP-Protected Indazole Boronic Ester; 5-Chloro-6-methyl-1-THP-4-boronic acid pinacol ester indazole; CAS 2374152-77-7
EINECS	Contact for details

Quality Control

Our 5-Chloro-6-Methyl-1-(Tetrahydro-2H-Pyran-2-Yl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided to guarantee the material meets the stringent requirements for pharmaceutical R&D and process development.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C or as specified on the label or COA. The material is hygroscopic (moisture-sensitive) and easily oxidized; therefore, containers must be kept sealed and allowed to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.