Description

8-Azabicyclo[3.2.1]Octane-8-Carboxylic Acid, 3-[(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Methylene]-, 1,1-Dimethylethyl Ester is a high-value, advanced pharmaceutical intermediate featuring a protected tropane scaffold and a versatile pinacol boronate ester functional group. This compound is specifically engineered for Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex carbon-carbon bonds. It is an essential building block for research and development chemists in the pharmaceutical and agrochemical industries, enabling the synthesis of novel bioactive molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting the central nervous system (CNS).
• Medicinal Chemistry Research: Used extensively in lead optimization and structure-activity relationship (SAR) studies via Suzuki-Miyaura cross-coupling.
• Agrochemical Synthesis: Serves as a building block for developing new active ingredients with potential herbicidal or insecticidal properties.
• Chemical Biology Probes: Facilitates the creation of labeled or tagged molecules for studying biological pathways and target engagement.
• Material Science: Potential monomer or precursor for specialty polymers and advanced organic materials.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development.

Basic Information

Product Name	8-Azabicyclo[3.2.1]Octane-8-Carboxylic Acid, 3-[(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Methylene]-, 1,1-Dimethylethyl Ester
CAS No.	2365173-53-9
Molecular Formula	C19H32BNO4
Molecular Weight	349.28 g/mol
Synonyms	tert-Butyl 3-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methylene)-8-azabicyclo[3.2.1]octane-8-carboxylate; 3-((4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)methylene)-8-azabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester; 8-Boc-3-methylene-8-azabicyclo[3.2.1]octane pinacol boronate; Tropane-3-methylene pinacol boronate N-Boc protected; Boronic ester tropane derivative
EINECS	Contact for details

Quality Control

Our 8-Azabicyclo[3.2.1]Octane-8-Carboxylic Acid, 3-[(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Methylene]-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.