Description

1-Pyrrolidinecarboxylic Acid, 3-[(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Methylene]-, 1,1-Dimethylethyl Ester, (3E)- is a high-value, advanced pharmaceutical intermediate featuring a strategically positioned boronic ester functional group. This compound matters as a critical building block in modern medicinal chemistry, enabling efficient cross-coupling reactions for the synthesis of complex, bioactive molecules. Pharmaceutical R&D and process chemistry teams need it for the development of novel active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) therapeutic areas.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for constructing carbon-carbon bonds in complex organic synthesis.
• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of novel Active Pharmaceutical Ingredients (APIs).
• Medicinal Chemistry & Drug Discovery: Used in the research and development of new drug candidates, especially for targeted therapies.
• Process Chemistry & Scale-Up: Employed in the optimization and large-scale production of pharmaceutical compounds.
• Ligand Synthesis: Can be utilized in the preparation of sophisticated ligands for catalysis.
• Material Science Research: Potential precursor for boron-containing polymers or advanced functional materials.

Basic Information

Item	Details
Product Name	1-Pyrrolidinecarboxylic Acid, 3-[(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Methylene]-, 1,1-Dimethylethyl Ester, (3E)-
CAS No.	2365173-49-3
Molecular Formula	C16H28BNO4
Molecular Weight	309.21 g/mol
Synonyms	(3E)-3-[(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)methylene]-1-(tert-butoxycarbonyl)pyrrolidine; tert-Butyl (3E)-3-[(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methylidene]pyrrolidine-1-carboxylate; (3E)-1-Boc-3-[(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methylene]pyrrolidine; 1-Boc-3-[(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methylene]pyrrolidine (E-isomer); BOC-protected pyrrolidine boronic ester; (E)-tert-Butyl 3-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methylene)pyrrolidine-1-carboxylate
EINECS	Contact for details

Quality Control

Our 1-Pyrrolidinecarboxylic Acid, 3-[(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Methylene]-, 1,1-Dimethylethyl Ester, (3E)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and isomeric integrity. Certificates of Analysis (COA) with detailed specifications are provided to guarantee compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and moisture-sensitive nature. Allow the container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Isomeric Purity (E/Z Ratio)	≥ 98:2 (E:Z)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.