Description

3-Cyano-2-Hydroxyphenylboronic Acid Pinacol Ester is a sophisticated boronic ester derivative that serves as a key protected intermediate in modern synthetic chemistry. Its value lies in its dual functionality, combining a nitrile group and a protected boronic acid moiety, which is essential for constructing complex molecular architectures via cross-coupling reactions. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel chemical entities.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A critical protected precursor for introducing the 2-hydroxy-3-cyanophenyl fragment into biaryl systems, a common scaffold in medicinal chemistry.
• Pharmaceutical Intermediate: Used in the research and development of potential drug candidates, particularly those requiring boronic acid handling in a stabilized, protected form.
• Agrochemical Synthesis: Serves as a building block for creating novel herbicides, fungicides, and insecticides with specific activity profiles.
• Material Science Research: Employed in the synthesis of organic electronic materials, ligands for catalysts, and advanced polymers where precise molecular control is required.
• Chemical Biology Probes: Useful for creating tagged molecules or inhibitors for studying biological pathways and enzyme functions.

Basic Information

Product Name	3-Cyano-2-Hydroxyphenylboronic Acid Pinacol Ester
CAS No.	2361216-95-5
Molecular Formula	C₁₄H₁₈BNO₃
Molecular Weight	259.11 g/mol
Synonyms	2-Hydroxy-3-cyanophenylboronic Acid Pinacol Ester; (2-Hydroxy-3-cyanophenyl)boronic Acid Pinacol Ester; 3-Cyano-2-hydroxybenzeneboronic Acid Pinacol Ester; 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-6-hydroxybenzonitrile; Pinacol (2-Hydroxy-3-cyanophenyl)boronate; Boronic Acid, B-(2-Hydroxy-3-cyanophenyl)-, 1,1,1',1'-tetramethyl-2,2'-bi-1,3,2-dioxaborolane Ester
EINECS	Contact for details

Quality Control

Our 3-Cyano-2-Hydroxyphenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistent performance for sensitive synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.