Description

4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole hydrochloride is a high-value, protected boronic ester derivative crucial for modern synthetic chemistry. This compound serves as a key pharmaceutical intermediate and building block in the development of novel active ingredients. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and material science sectors for advanced cross-coupling reactions and molecular scaffold construction.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Suzuki-Miyaura Cross-Coupling Reactions: The protected boronic ester functionality makes it an ideal, stable reagent for palladium-catalyzed carbon-carbon bond formation.
• Agrochemical Research: Used in the discovery and development of new herbicides, fungicides, and insecticides with novel modes of action.
• Material Science & Organic Electronics: Serves as a precursor for creating complex organic molecules used in OLEDs, sensors, and conductive polymers.
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes and activity-based protein profiling (ABPP) reagents.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects requiring precise, functionalized heterocyclic cores.

Basic Information

Item	Details
Product Name	4-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole Hydrochloride
CAS No.	2345598-03-8
Molecular Formula	C10H18BN2O2·HCl
Molecular Weight	260.54 g/mol
Synonyms	4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole HCl; 1H-Pyrazole, 4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, hydrochloride; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-methyl-1H-pyrazole hydrochloride; Pinacol 4-Methyl-1H-pyrazole-3-boronate hydrochloride; 4-Methyl-1H-pyrazole-3-boronic acid pinacol ester hydrochloride
EINECS	Contact for details

Quality Control

Our 4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment aligns with the standards expected for GMP-grade intermediates and advanced chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the primary container to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.