Description

1,3,2-Dioxaborolane, 2-[5-Fluoro-2-Methoxy-4-(Trifluoromethyl)Phenyl]-4,4,5,5-Tetramethyl- is a high-purity, advanced pharmaceutical intermediate and versatile organoboron building block. Its core value lies in enabling efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, which are fundamental for constructing complex molecules in modern synthetic chemistry. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality precursors for drug discovery and development.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing fluorinated and trifluoromethylated aromatic systems.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds to create complex biaryl structures, a cornerstone reaction in medicinal chemistry.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that leverage its unique fluorinated phenylboronate structure.
• Material Science Research: Serves as a precursor for developing organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Chemical Biology & Probe Development: Utilized in the creation of molecular probes and bioconjugates for diagnostic and research applications.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Product Name	1,3,2-Dioxaborolane, 2-[5-Fluoro-2-Methoxy-4-(Trifluoromethyl)Phenyl]-4,4,5,5-Tetramethyl-
CAS No.	2311855-36-2
Molecular Formula	C14H17BF4O3
Molecular Weight	320.09 g/mol
Synonyms	5-Fluoro-2-methoxy-4-(trifluoromethyl)phenylboronic acid pinacol ester; [5-Fluoro-2-methoxy-4-(trifluoromethyl)phenyl]boronic acid pinacol ester; 2-(5-Fluoro-2-methoxy-4-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 5-Fluoro-2-methoxy-4-trifluoromethylbenzeneboronic acid pinacol ester; 4,4,5,5-Tetramethyl-2-[5-fluoro-2-methoxy-4-(trifluoromethyl)phenyl]-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 1,3,2-Dioxaborolane, 2-[5-Fluoro-2-Methoxy-4-(Trifluoromethyl)Phenyl]-4,4,5,5-Tetramethyl- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high purity and batch-to-batch consistency suitable for demanding applications like pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its hygroscopic nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) and at temperatures between 2°C and 8°C for long-term stability. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.