Description

4-Fluoroindolin-7-Amine Dihydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a fluorinated indoline scaffold. This compound is of significant value in medicinal chemistry for the synthesis of novel drug candidates, particularly in the development of kinase inhibitors and other targeted therapies. It is primarily sought by research institutions, CROs/CDMOs, and pharmaceutical companies engaged in the discovery and process development of new chemical entities.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex molecules for preclinical and clinical research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize potency and selectivity of drug leads.
• Kinase Inhibitor Development: The fluorinated indoline core is a privileged structure in the design of protein kinase inhibitors for oncology and inflammatory diseases.
• Process Chemistry & Scale-Up: Serves as a critical starting material or intermediate for route scouting and GMP manufacturing of active pharmaceutical ingredients (APIs).
• Chemical Biology Probes: Can be utilized to create tool compounds for studying biological pathways and target validation.
• Custom Synthesis: A versatile substrate for further functionalization and the creation of proprietary compound libraries.

Basic Information

Product Name	4-Fluoroindolin-7-Amine Dihydrochloride
CAS No.	2306274-49-5
Molecular Formula	C8H11Cl2FN2
Molecular Weight	225.09 g/mol
Synonyms	7-Amino-4-fluoroindoline dihydrochloride; 4-Fluoro-7-aminoindoline hydrochloride; 4-Fluoroindolin-7-amine hydrochloride; 4-Fluoro-1H-indol-7-amine dihydrochloride; 4-Fluoro-2,3-dihydro-1H-indol-7-amine dihydrochloride; 2306274-49-5; 4-Fluoro-7-indolinamine dihydrochloride
EINECS	Contact for details

Quality Control

Our 4-Fluoroindolin-7-Amine Dihydrochloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. We provide comprehensive analytical data including HPLC purity, NMR, and mass spectrometry. A Certificate of Analysis (COA) is supplied with each batch, and custom purity grades or analytical packages can be discussed to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a controlled environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.