Description

tert-Butyl 4-(2-Oxoethyl)Bicyclo[2.2.1]Heptane-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its unique norbornane-derived bicyclic structure. This compound is critical for synthetic chemists as it provides a versatile, functionalized scaffold for constructing complex molecules in medicinal chemistry. It is primarily utilized in the research and development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral therapeutics.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, especially those targeting neurological pathways.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies due to its rigid bicyclic framework.
• Protease Inhibitor Development: Serves as a precursor in the synthesis of inhibitors for various viral and metabolic proteases.
• Asymmetric Synthesis: Employed in chiral synthesis protocols to introduce stereocenters in complex organic molecules.
• Peptidomimetics: The norbornane core is used to create conformationally restricted peptide analogs for enhanced biological stability.
• Material Science Precursor: Potential use in synthesizing specialized monomers for high-performance polymers.

Basic Information

Product Name	tert-Butyl 4-(2-Oxoethyl)Bicyclo[2.2.1]Heptane-1-Carboxylate
CAS No.	2306264-46-8
Molecular Formula	C15H24O3
Molecular Weight	252.35 g/mol
Synonyms	1-Bicyclo[2.2.1]heptane-1-carboxylic acid, 4-(2-oxoethyl)-, 1,1-dimethylethyl ester; tert-Butyl 4-(2-oxoethyl)norbornane-1-carboxylate; 4-(2-Oxoethyl)bicyclo[2.2.1]heptane-1-carboxylic acid tert-butyl ester; Norbornane tert-butyl ester oxoethyl derivative; Bicyclo[2.2.1]heptane tert-butyl keto-ester; TB-4-OE-BH Carboxylate; 2306264-46-8
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(2-Oxoethyl)Bicyclo[2.2.1]Heptane-1-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our production adheres to cGMP guidelines where applicable, ensuring suitability for use in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.