Description

1-Azetidinecarboxylic Acid, 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-, 1,1-Dimethylethyl Ester is a high-value, advanced pharmaceutical intermediate featuring a unique azetidine ring functionalized with a pinacol boronate ester. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules through versatile cross-coupling reactions. It is primarily needed by R&D scientists and process chemists in the pharmaceutical and agrochemical industries for developing new active ingredients.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for introducing the azetidine moiety into complex molecular architectures, enabling C-C bond formation in drug discovery.
• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel drug candidates, particularly in areas like protease inhibitors and kinase modulators.
• Agrochemical Research: Used in the development of new pesticides and herbicides with novel modes of action.
• Peptidomimetics & Bioisosteres: The azetidine ring acts as a constrained scaffold or bioisostere for amide bonds in peptide-based drug design.
• Material Science Research: Potential building block for creating functional polymers and advanced organic materials with specific properties.
• Chemical Biology Probes: Utilized in the synthesis of tool compounds and probes for studying biological pathways and target engagement.

Basic Information

Product Name	1-Azetidinecarboxylic Acid, 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-, 1,1-Dimethylethyl Ester
CAS No.	2304635-53-6
Molecular Formula	C14H26BNO4
Molecular Weight	283.18 g/mol
Synonyms	tert-Butyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)azetidine-1-carboxylate; 1-Boc-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)azetidine; 3-(Pinacolatoboryl)azetidine-1-carboxylic acid tert-butyl ester; 1-N-Boc-3-boronic acid pinacol ester azetidine; Azetidine-1-carboxylic acid, 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, 1,1-dimethylethyl ester; 3-Boc-azetidine-3-boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 1-Azetidinecarboxylic Acid, 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive and light-sensitive nature. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.