Description

3-Chloro-6-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-1H-Indole is a high-value, multi-functional indole-based boronic ester building block. This compound is critical for modern synthetic chemistry, enabling the rapid construction of complex molecular architectures through efficient cross-coupling reactions. It is primarily utilized by pharmaceutical and agrochemical R&D organizations for the discovery and development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used to create advanced active ingredients for crop protection products, leveraging the indole and boronate functionalities.
• Material Science Research: Serves as a building block for organic electronic materials, such as OLEDs and conductive polymers, due to its conjugated indole core.
• Chemical Biology Probes: Employed in the development of molecular probes and sensors for studying biological processes.
• Catalyst Ligand Synthesis: Used to prepare sophisticated ligands for transition metal catalysis.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs serving the global life sciences industry.

Basic Information

Product Name	3-Chloro-6-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-1H-Indole
CAS No.	2304635-36-5
Molecular Formula	C14H17BClNO2
Molecular Weight	277.55 g/mol
Synonyms	3-Chloro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole; 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-chloro-1H-indole; 3-Chloro-6-(pinacolatoboryl)-1H-indole; 3-Chloro-1H-indole-6-boronic acid pinacol ester; Pinacol 3-chloro-1H-indole-6-boronate; 2304635-36-5; 3-Chloro-6-(pinacolboron)-1H-indole
EINECS	Contact for details

Quality Control

Our 3-Chloro-6-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-1H-Indole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for sensitive R&D and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.