Description

H-Pyrazolo[3,4-B]Pyridine-4-Boronic Acid is a high-value boronic acid derivative and a key heterocyclic building block in modern synthetic chemistry. This compound matters for its crucial role as a versatile coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily needed by research scientists and process chemists in the pharmaceutical and agrochemical industries for the development of new active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly in kinase inhibitor research and other small molecule therapeutics.
• Agrochemical Synthesis: Used to construct complex heterocyclic scaffolds found in advanced pesticides, herbicides, and fungicides.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as those used in OLEDs and organic semiconductors.
• Chemical Biology & Probe Development: Employed in the creation of molecular probes and labeled compounds for biological target identification and validation.
• Cross-Coupling Reactions: Primarily utilized in palladium-catalyzed Suzuki-Miyaura reactions to form carbon-carbon bonds with high efficiency and selectivity.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for custom synthesis projects requiring specific, high-purity boronic acid derivatives.

Basic Information

Product Name	H-Pyrazolo[3,4-B]Pyridine-4-Boronic Acid
CAS No.	2304635-23-0
Molecular Formula	C6H6BN3O2
Molecular Weight	162.94 g/mol
Synonyms	1H-Pyrazolo[3,4-b]pyridine-4-boronic acid; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazolo[3,4-b]pyridine; Pyrazolo[3,4-b]pyridin-4-ylboronic acid; 1H-Pyrazolo[3,4-b]pyridine-4-ylboronic acid; 4-Borono-1H-pyrazolo[3,4-b]pyridine; CAS 2304635-23-0
EINECS	Contact for details

Quality Control

Our H-Pyrazolo[3,4-B]Pyridine-4-Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency suitable for sensitive synthetic applications. Comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.