Description

4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-6-(Trifluoromethyl)-2,3-Dihydro-1H-Indol-2-One CAS NO 2304635-22-9 is a high-purity, advanced pharmaceutical intermediate featuring a pinacol boronate ester group and a trifluoromethyl-substituted indolinone core. This compound is a critical building block in modern medicinal chemistry, enabling efficient cross-coupling reactions like the Suzuki-Miyaura reaction for constructing complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of novel active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially those targeting protein kinases and other enzymes.
• Suzuki-Miyaura Cross-Coupling: The pinacol boronate ester moiety serves as a versatile handle for forming carbon-carbon bonds with aryl/heteroaryl halides, a cornerstone reaction in drug discovery.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical space and improve drug-like properties.
• Development of Trifluoromethylated Compounds: The -CF3 group is a privileged motif in drug design for enhancing metabolic stability, lipophilicity, and binding affinity.
• Chemical Biology Probes: Can be incorporated into molecules designed to study biological pathways and protein functions.
• Agrochemical Research: Potential intermediate in the development of novel herbicides or fungicides containing the indolinone scaffold.

Basic Information

Product Name	4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-6-(Trifluoromethyl)-2,3-Dihydro-1H-Indol-2-One
CAS No.	2304635-22-9
Molecular Formula	C15H17BF3NO3
Molecular Weight	327.11 g/mol
Synonyms	6-(Trifluoromethyl)-2,3-dihydro-1H-indol-2-one, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trifluoromethyl)indolin-2-one; 6-Trifluoromethyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1,3-dihydro-indol-2-one; 4-BPin-6-CF3-indolin-2-one; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trifluoromethyl)-2,3-dihydro-1H-indol-2-one; 2-Oxo-6-(trifluoromethyl)-2,3-dihydro-1H-indole-4-boronic acid pinacol ester
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Quality Control

Our 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-6-(Trifluoromethyl)-2,3-Dihydro-1H-Indol-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our production adheres to cGMP principles suitable for pharmaceutical R&D applications, ensuring reliable batch-to-batch consistency for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage temperature is 2-8°C (refrigerated) or -20°C for extended periods.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.