Description

3-Methyl-1H-Indazole-4-Boronic Acid Picol Ester is a high-value boronic ester derivative, a crucial building block in modern synthetic organic chemistry. Its primary value lies in its role as a protected boronic acid, offering enhanced stability and solubility for use in cross-coupling reactions, most notably the Suzuki-Miyaura reaction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries who are developing novel active ingredients, particularly in the synthesis of complex heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those containing indazole and other fused heterocyclic systems.
• Suzuki-Miyaura Cross-Coupling Reagent: Used as a stable organoboron reagent for the formation of carbon-carbon bonds, enabling the construction of complex molecular architectures.
• Agrochemical Research: Serves as a building block in the development of new herbicides, fungicides, and insecticides with improved efficacy.
• Material Science: Potential use in the synthesis of organic electronic materials and metal-organic frameworks (MOFs).
• Chemical Biology & Proteomics: Can be utilized in the development of chemical probes and inhibitors for studying biological pathways.
• Process Chemistry & Scale-up: Employed in the development and optimization of scalable synthetic routes for active pharmaceutical ingredients (APIs).

Basic Information

Item	Detail
Product Name	3-Methyl-1H-Indazole-4-Boronic Acid Picol Ester
CAS No.	2304635-16-1
Molecular Formula	C15H14BN3O2
Molecular Weight	279.11 g/mol
Synonyms	3-Methyl-1H-indazole-4-boronic acid picolinyl ester; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-methyl-1H-indazole (tautomer/precursor related); 3-Methyl-4-(pyridin-2-yloxy)indazole-1-boronic acid ester; Boronic acid, B-[3-methyl-1H-indazol-4-yl]-, 2-pyridinyl ester; 3-Methyl-1H-indazole-4-boronic acid 2-pyridyl ester; Picol ester of 3-Methyl-1H-indazole-4-boronic acid
EINECS	Contact for details

Quality Control

Our 3-Methyl-1H-Indazole-4-Boronic Acid Picol Ester is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR (1H, 13C, 11B) for structural confirmation, and mass spectrometry. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.