Description

{5-Fluoro-1-[Tris(Propan-2-Yl)Silyl]-1H-Indol-4-Yl}Boronic Acid is a sophisticated organoboron building block featuring a fluorinated indole core protected by a bulky tris(isopropyl)silyl (TIPS) group. This compound is specifically engineered for advanced cross-coupling reactions, such as the Suzuki-Miyaura reaction, where its steric protection and fluorine substituent enable precise molecular construction. It is an essential intermediate for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly in medicinal chemistry for creating complex heterocyclic scaffolds. The CAS number for this compound is 2304635-01-4.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially for creating fluorinated indole-based molecules with potential therapeutic activity.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where the fluorine atom and boronic acid group allow for the introduction of specific bioactive properties.
• Material Science Precursor: Serves as a monomer or functional unit in the synthesis of advanced organic electronic materials, such as OLEDs or conductive polymers.
• Suzuki-Miyaura Cross-Coupling: Primarily utilized in palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds, enabling the efficient assembly of complex, biaryl structures.
• Medicinal Chemistry Library Synthesis: Enables the rapid generation of diverse compound libraries for high-throughput screening in drug discovery programs.
• Chemical Biology Probes: Used to create tagged or modified molecules for studying biological processes and protein interactions.

Basic Information

Product Name	{5-Fluoro-1-[Tris(Propan-2-Yl)Silyl]-1H-Indol-4-Yl}Boronic Acid
CAS No.	2304635-01-4
Molecular Formula	C20H31BFNOSi
Molecular Weight	359.37 g/mol
Synonyms	5-Fluoro-1-[tris(propan-2-yl)silyl]-1H-indol-4-ylboronic acid; 1H-Indole-4-boronic acid, 5-fluoro-1-[tris(1-methylethyl)silyl]-; 5-Fluoro-1-(triisopropylsilyl)-1H-indol-4-ylboronic acid; 5-Fluoro-1-TIPS-indol-4-ylboronic acid; 4-Borono-5-fluoro-1-triisopropylsilylindole; TIPS-Protected 5-Fluoroindole-4-boronic Acid; (5-Fluoro-1-triisopropylsilyl-1H-indol-4-yl)boronic acid
EINECS	Contact for details

Quality Control

Our {5-Fluoro-1-[Tris(Propan-2-Yl)Silyl]-1H-Indol-4-Yl}Boronic Acid is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for research and scale-up applications. Each batch is analyzed using advanced techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when possible to maintain stability. For long-term storage, consider storing desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥95% (Typical: 97-99%)
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.